Balanced amplification

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Supplemental Materials for “Balanced amplification: a new mechanism of selective amplification of neural activity patterns”

S1 Mathematical Solutions and Analysis of the Models Studied in the Main Text 2 S1.1 Two-Population Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 S1.1.1 Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 S1.1.2 Applications to Results in the Main Text . . . . . . . . . . . . . . . . 4 S1.1.3 Paradoxical Effects of Input to Inhibitory Cells . . ...

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Balanced Amplification: A New Mechanism of Selective Amplification of Neural Activity Patterns

In cerebral cortex, ongoing activity absent a stimulus can resemble stimulus-driven activity in size and structure. In particular, spontaneous activity in cat primary visual cortex (V1) has structure significantly correlated with evoked responses to oriented stimuli. This suggests that, from unstructured input, cortical circuits selectively amplify specific activity patterns. Current understand...

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Non-normal amplification in random balanced neuronal networks.

In dynamical models of cortical networks, the recurrent connectivity can amplify the input given to the network in two distinct ways. One is induced by the presence of near-critical eigenvalues in the connectivity matrix W, producing large but slow activity fluctuations along the corresponding eigenvectors (dynamical slowing). The other relies on W not being normal, which allows the network act...

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Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples.

Analysis of genomic DNA derived from cells and fresh or fixed tissues often requires whole genome amplification prior to microarray screening. Technical hurdles to this process are the introduction of amplification bias and/or the inhibitory effects of formalin fixation on DNA amplification. Here we demonstrate a balanced-PCR procedure that allows unbiased amplification of genomic DNA from fres...

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Remarks on Distance-Balanced Graphs

Distance-balanced graphs are introduced as graphs in which every edge uv has the following property: the number of vertices closer to u than to v is equal to the number of vertices closer to v than to u. Basic properties of these graphs are obtained. In this paper, we study the conditions under which some graph operations produce a distance-balanced graph.

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ژورنال

عنوان ژورنال: Genome Biology

سال: 2002

ISSN: 1465-6906

DOI: 10.1186/gb-spotlight-20020809-01